Smokeless tobacco is an established cause of several cancers, including cancers of the mouth. DNA adducts form when certain chemicals bind to DNA and are considered important steps in the process that can lead to cancer.
This study compared oral cells from 24 people who used smokeless tobacco with 25 people who used no tobacco or nicotine products. Several measured DNA adducts were significantly higher among smokeless tobacco users.
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View Original SourceDNA damage is important because repeated or unrepaired genetic damage can contribute to cancer development.
This study provides direct measurements from human oral cells and helps researchers understand some of the biological changes associated with smokeless tobacco use.
Smokeless tobacco does not involve smoke, but that does not mean it is harmless. Products placed in the mouth can expose oral tissues to carcinogens and other toxic chemicals.
Findings on DNA damage can support public health communication and regulation of smokeless tobacco products, particularly when products are promoted as alternatives to cigarettes.
اس تحقیق میں بغیر دھوئیں والے تمباکو استعمال کرنے والے 24 افراد اور تمباکو یا نکوٹین استعمال نہ کرنے والے 25 افراد کے منہ کے خلیات کا موازنہ کیا گیا۔ محققین نے ڈی این اے کے ساتھ جڑنے والے کئی کیمیائی نشانات کو ناپا۔
ان میں سے کئی ڈی این اے سے جڑنے والے کیمیائی نشانات تمباکو استعمال کرنے والوں میں نمایاں طور پر زیادہ تھے۔ ایسے نشانات سرطان بننے کے عمل میں اہم ہو سکتے ہیں۔ اس تحقیق سے یہ واضح ہوتا ہے کہ بغیر دھوئیں والا تمباکو بھی منہ کے خلیات کو نقصان پہنچانے والے کیمیکلز سے نمائش کا باعث بن سکتا ہے۔
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