Nicotine from cigarette smoke can cause oxidative stress, leading to vascular endothelial dysfunction, a key factor in cardiovascular diseases. Piper sarmentosum Roxb., a medicinal herb, has known antioxidant and vascular protective properties.
This study investigates whether an aqueous extract of P. sarmentosum leaves (AEPS) can mitigate vascular damage caused by prolonged nicotine exposure in rats, suggesting potential natural interventions for vascular health.